"Daily proportion of patients meeting the criteria for hyperinflammation from the day of symptom onset until the day that respiratory support was escalated."

Johns Hopkins University

In a retrospective longitudinal cohort study, researchers aimed to investigate a phenotype of COVID-19-associated hyperinflammation (COV-HI) and how it is linked to survival and the escalation of patient care support.  The researchers established a COV-HI criteria to assess 269 COVID-19 patients.  To meet the criteria for COV-HI, patients had to have "C-reactive protein concentration >150 mg/L or doubling within 24 h from >50 mg/L, or ferritin concentration >1500 μg/L."  The COV-HI criteria was met by 90 of the COVID-19 patients, and patients with COVI-HI had a higher likelihood of dying than the patients without COV-HI.  Furthermore, having COV-HI was significantly linked to a higher risk of requiring escalation of respiratory support and death.  These findings are indicative of COV-HI being a high-risk inflammatory phenotype that could potentially be helpful to use to analyze disease severity and survival.  

COVID-19-Associated Hyperinflammation and Escalation of Patient Care: a retrospective longitudinal cohort study

Manson, J. J., Crooks, C., Naja, M., Ledlie, A., Goulden, B., Liddle, T., . . . Tattersall, R. S. (2020). COVID-19-associated hyperinflammation and escalation of patient care: A retrospective longitudinal cohort study. The Lancet Rheumatology. doi:10.1016/s2665-9913(20)30275-7

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