In a retrospective longitudinal cohort study, researchers aimed to investigate a phenotype of COVID-19-associated hyperinflammation (COV-HI) and how it is linked to survival and the escalation of patient care support. The researchers established a COV-HI criteria to assess 269 COVID-19 patients. To meet the criteria for COV-HI, patients had to have "C-reactive protein concentration >150 mg/L or doubling within 24 h from >50 mg/L, or ferritin concentration >1500 μg/L." The COV-HI criteria was met by 90 of the COVID-19 patients, and patients with COVI-HI had a higher likelihood of dying than the patients without COV-HI. Furthermore, having COV-HI was significantly linked to a higher risk of requiring escalation of respiratory support and death. These findings are indicative of COV-HI being a high-risk inflammatory phenotype that could potentially be helpful to use to analyze disease severity and survival.