Red text denotes the Malayan Pangolin-CoV. Pink text denotes SARS-CoV-2. Green text denotes a bat CoV with 96% similarity at the genome level to SARSCoV-2. Blue text denotes the reference CoVs used in Figure 1B.

University of Michigan - Ann Arbor

Phylogenetic relationships were developed using whole genome sequences, RNA-dependent RNA polymerase genes, ORF1a and ORF1b (non-structural protein genes), and S and M gene-encoded structural proteins. All phylogenies support the close relationship between Pangolin-CoV, RaTG13, and SARS-CoV-2, with RaTG13 and SARS-CoV-2 being grouped together and Pangolin-CoV as a common ancestor. 

Pangolin-CoV is the second closest relative of SARS-CoV-2 behind RaTG13

Zhang, T., Wu, Q., & Zhang, Z. (2020). Probable Pangolin Origin of SARS-CoV-2 Associated with the COVID-19 Outbreak. Current biology : CB, 30(7), 1346–1351.e2. https://doi.org/10.1016/j.cub.2020.03.022

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