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Pangolin-CoV is the second closest relative of SARS-CoV-2 behind RaTG13
Phylogenetic relationships were developed using whole genome sequences, RNA-dependent RNA polymerase genes, ORF1a and ORF1b (non-structural protein genes), and S and M gene-encoded structural proteins. All phylogenies support the close relationship between Pangolin-CoV, RaTG13, and SARS-CoV-2, with RaTG13 and SARS-CoV-2 being grouped together and Pangolin-CoV as a common ancestor.
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SARS-CoV-2 (COVID-19)
Biomedical Sciences
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Graphical Abstract of Probable Pangolin Origin of SARS-CoV-2 Associated with the COVID-19 Outbreak
Pangolin-CoV is 91.02% identical to SARS-CoV-2 at the whole-genome level
Pangolin-CoV is the second closest relative of SARS-CoV-2 behind RaTG13
Five key amino acids in the RBD are consistent between Pangolin-CoV and SARS-CoV-2
Only SARS-CoV-2 contains a potential cleavage site for furin proteases