(A) The dynamic change of S1 and N specific IgM antibody responses. 
(B) The dynamic change of S1 and N specific IgG antibody responses. 

Lines indicate antibody responses against SARS-CoV-2 at different times after exposure (for asymptomatic and healthy contacts) or after symptom onset (among mild cases). The bars indicate medians and IQR.

University of Michigan - Ann Arbor

S1 and N IgM/IgG responses showed in asymptomatic individuals 7 days post-exposure and were greatest 17-25 days post-exposure. S1 IgM and IgG responses and titers of neutralizing antibodies disappeared after 2 months post-exposure. S1 IgM antibody responses showed in mild individuals after 1 day of symptom onset, increasing until 29 days after onset. Mild patients experience greater N-specific responses for IgM/IgG, remaining over 65 days. 63.5% asymptomatic cases and 19% of healthy individuals induced titers of neutralizing antibodies (mean NT50 1:24 and 1:13). The neutralizing antibody response among asymptomatic individuals occurred after 7 day post-exposure, and peaked from 10-25 days. 88.2% of mild cases induced titers (mean NT50 1:269), occurring 1 day following symptom onset, and peaked at 22 days.

Antibody dynamics to SARS-CoV-2 in Asymptomatic and Mild COVID-19 patients: Results

Lei, Q., Hou, H., Wang, F., et al. 2020. Antibody dynamics to SARS-CoV-2 in Asymptomatic and Mild COVID-19 patients. 
* https://doi.org/10.1101/2020.07.09.20149633

Antibody dynamics to SARS-CoV-2 in Asymptomatic and Mild COVID-19 patients

Figure: The dynamic change of S1 and N specific IgM and IgG antibody responses

(A) Comparison of the titers of neutralizing antibody in different groups. 
(B) Comparison of the titers of neutralizing antibody in different subgroups of asymptomatic individuals and mild patients with that of healthy contacts. (C) The dynamic change of the titers of neutralizing antibody over time. 

Lines indicate change of neutralizing ability at different times after exposure (asymptomatic cases and healthy contacts) or after symptom onset (mild cases). Samples with neutralizing titers below 1:10 were plotted at the dotted line (log2NT50=1). Statistical significance in A and B was determined using unpaired t-test, horizontal bars indicate mean and SD.

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