Concept

Antibody dynamics to SARS-CoV-2 in Asymptomatic and Mild COVID-19 patients: Results

S1 and N IgM/IgG responses showed in asymptomatic individuals 7 days post-exposure and were greatest 17-25 days post-exposure. S1 IgM and IgG responses and titers of neutralizing antibodies disappeared after 2 months post-exposure. S1 IgM antibody responses showed in mild individuals after 1 day of symptom onset, increasing until 29 days after onset. Mild patients experience greater N-specific responses for IgM/IgG, remaining over 65 days. 63.5% asymptomatic cases and 19% of healthy individuals induced titers of neutralizing antibodies (mean NT50 1:24 and 1:13). The neutralizing antibody response among asymptomatic individuals occurred after 7 day post-exposure, and peaked from 10-25 days. 88.2% of mild cases induced titers (mean NT50 1:269), occurring 1 day following symptom onset, and peaked at 22 days.

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Updated 2020-07-24

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SARS-CoV-2 (COVID-19)

Biomedical Sciences