Ohio State University, Columbus

It was observed that there was greater staining in cells which the ORF3a accessory protein was expressed indicating a potential link between ORF3a and pro-apoptotic activity seen in host cells. Further evidence on top of the staining patterns was provided by the increased rate of apoptosis seen in host cells that had the ORF3a protein expressed.

Results of Apoptosis Rate and FITC/PI Staining based on Expression of ORF3a of SARS-CoV2 of HEK293T, HepG2, and Vero E6 cells

Ren, Y., Shu, T., Wu, D. et al. The ORF3a protein of SARS-CoV-2 induces apoptosis in cells. Cell Mol Immunol 17, 881–883 (2020). https://doi.org/10.1038/s41423-020-0485-9

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