The balance between inhibitory neurotransmitter GABA and excitatory neurotransmitter glutamate appears to be important in aggressive response to stimuli; antiaggression treatment based on these research

University of Michigan - Ann Arbor

Aggressive behavior is modulated by neurotransmitter systems.
- Negative correlation between serotonin and aggression
- GABA and aggression
- Ventromedial hypothalamus (VMH)

Aggression has several neurochemical correlates

- Gamma-aminobutyric acid (GABA) 
- The main inhibitory neurotransmitter in the mammalian nervous system
- GABA receptors are divided to large classes: GABA A (ionotropic), GABA B (metabotropic) , GABA C (ionotropic)

GABA

Breedlove, S. & Watson, N. (2017). Behavioral neuroscience, eighth edition. Oxford University Press.

Behavioral Neuroscience 8th Edition

In a study, the most aggressive monkeys had the lowest levels of serotonin metabolites, which means they had the least serotonin released; mice with one of the serotonin receptor knocked out are hyper-aggressive; inhibitory role

Negative correlation between serotonin and aggression

GABA and aggression

experiments on mice: stimulate neurons in this area, the male mice would stop mounting a receptive female mice and start to attack her

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