Certain microbiota enhances the efficacy of many chemotherapies and immunotherapies.

Gut Microbiome and Cancer Treatment Efficacy

"Using subcutaneous and liver metastases models of pancreatic cancer, colon cancer and melanoma, Sethi et al showed that antibiotics-mediated suppression of tumour growth involved adaptive immunity. This inhibitory effect was attenuated in Rag1-knockout mice that were deficient in mature T and B cells" ("The role of gut microbiota in cancer treatment: friend or foe?").

Gut Microbiome and Cancer Growth/Progression

- Bacteria and cancer treatment efficacy
- Bacteria that promote cancer progression

University of Michigan - Ann Arbor

- Metabolic diseases
- Type-1, 2 diabetes
- Cardiovascular disease
- Inflammatory bowel disease (IBD) and Irritable bowel syndrome (IBS)
- Multiple sclerosis

Gut Microbiome and Human Diseases

Gut Microbiome and Cancer

Study in mice:
- Colonization of microbiomes increases LPL-triglyceride storage
- Lipopolysaccharide (LPS) in gut can lead to inflammatory; hence, result in obesity

Metabolic Diseases

Type-1 Diabetes may be influenced by:
- Decreased in diversity of gut microbiome
- Functions related to stress response, sulfur metabolism, etc. are enhanced

Type-2 Diabetes may be associated with:
- Imbalanced of microbiomes

Type-1,2 Diabetes

- Specific microbiomes, whose function is synthesizing peptidoglycan, is increased in number.
- The production of Trimethylamine from microbiomes promotes atherosclerosis.

Cardiovascular Diseases

- IBD and subtypes IBS patients presents specific composition of microbiome, including the reduction of anti-inflammatory bacteria

Ex: Crohn's disease: observes the decrease in microbial diversity


Inflammatory Bowel Disease (IBD)/ Irritable Bowel Syndrome (IBS)

Multiple sclerosis (MS) is an autoimmune disorder characterized by the widespread loss of the myelin sheath on axons throughout the nervous system. This damage interferes with the electrical signal, preventing the rapid transmission of information between neurons. Symptoms can include dizziness, fatigue, loss of motor control, and sexual dysfunction. While treatments can help manage symptoms and modify the disease's course, there is currently no known cure for MS.

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