- Bacteria and cancer treatment efficacy
- Bacteria that promote cancer progression

Gut Microbiome and Cancer

Study in mice:
- Colonization of microbiomes increases LPL-triglyceride storage
- Lipopolysaccharide (LPS) in gut can lead to inflammatory; hence, result in obesity

Metabolic Diseases

Type-1 Diabetes may be influenced by:
- Decreased in diversity of gut microbiome
- Functions related to stress response, sulfur metabolism, etc. are enhanced

Type-2 Diabetes may be associated with:
- Imbalanced of microbiomes

Type-1,2 Diabetes

- Specific microbiomes, whose function is synthesizing peptidoglycan, is increased in number.
- The production of Trimethylamine from microbiomes promotes atherosclerosis.

Cardiovascular Diseases

- IBD and subtypes IBS patients presents specific composition of microbiome, including the reduction of anti-inflammatory bacteria

Ex: Crohn's disease: observes the decrease in microbial diversity


Inflammatory Bowel Disease (IBD)/ Irritable Bowel Syndrome (IBS)

Multiple sclerosis (MS) is an autoimmune disorder characterized by the widespread loss of the myelin sheath on axons throughout the nervous system. This damage interferes with the electrical signal, preventing the rapid transmission of information between neurons. Symptoms can include dizziness, fatigue, loss of motor control, and sexual dysfunction. While treatments can help manage symptoms and modify the disease's course, there is currently no known cure for MS.

Multiple Sclerosis

- Metabolic diseases
- Type-1, 2 diabetes
- Cardiovascular disease
- Inflammatory bowel disease (IBD) and Irritable bowel syndrome (IBS)
- Multiple sclerosis

University of California, Davis

University of Georgia

Gut Microbiome (i.e gut flora or gut microbiota) is the collection of microbes (and/ or their genomes) that exist in the gut. 

 Gut Microbiome

(1) Willey, J.. Prescott's Microbiology. McGraw-Hill Higher Education, 11th ed. (2020), c.34.

(2) Thursby, Elizabeth, and Nathalie Juge. “Introduction to the human gut microbiota.” The Biochemical journal vol. 474,11 1823-1836. 16 May. 2017, doi:10.1042/BCJ20160510

(3) Jessica Cording, M.S. “Want To Avoid Gas & Bloating At Holiday Parties? Don't Eat This Healthy Food.” Mindbodygreen, Mindbodygreen, 29 Sept. 2020,www.mindbodygreen.com/articles/how-cruciferous-vegetables-can-cause-gas-and-bloating . 

(4) John P. Cunha, DO. “Low FODMAP Diet for IBS: List of Foods to Eat and Avoid.” MedicineNet, MedicineNet, 17 Feb. 2021, www.medicinenet.com/low_fodmap_diet_list_of_foods_to_eat_and_avoid/article.htm#:~:text=FODMAPs%20are%20not%20absorbed%20well,Gas. 

(5) Jessica Cording, M.S. et al.  “Want To Avoid Gas &amp; Bloating At Holiday Parties? Don't Eat This Healthy Food.” Mindbodygreen, Mindbodygreen, 29 Sept. 2020, www.mindbodygreen.com/articles/how-cruciferous-vegetables-can-cause-gas-and-bloating. 

(6) Doucleff, Michaeleen. “Chowing down on Meat, Dairy Alters Gut Bacteria a Lot, and Quickly.” NPR, NPR, 11 Dec. 2013, www.npr.org/sections/thesalt/2013/12/10/250007042/chowing-down-on-meat-and-dairy-alters-gut-bacteria-a-lot-and-quickly. 

(7)Villines, Zawn. “The Worst Foods for Gut Health.” Medical News Today, MediLexicon International, 5 Sept. 2019, www.medicalnewstoday.com/articles/326256#:~:text=A%202019%20study%20suggested%20that,of%20heart%20attack%20and%20stroke. 

(8) Ana Maldonado-Contreras Assistant Professor of Microbiology and Physiological Systems. “A Healthy Microbiome Builds a Strong Immune System That Could Help Defeat Covid-19.” The Conversation, 25 May 2021, theconversation.com/a-healthy-microbiome-builds-a-strong-immune-system-that-could-help-defeat-covid-19-145668. 

(9) “How Your Gut Affects Your Immune System: A Symbiotic Relationship.” GilbertLab, 8 June 2021, gilbertlab.com/immune-system/gut-microbiome-symbiosis/.  

(10) Zanteson, Lori. “Gut Health and Immunity - It's All about the Good Bacteria That Can Help Fight Disease.” Today's Dietitian, 2012, www.todaysdietitian.com/newarchives/060112p58.shtml. 


Microbiomes References

- Helps maintaining the integrity of mucosal barrier
   
- Provides nutrients

- Protect against pathogens
  


Roles of the Gut Microbiomes

Gut Microbiome and Human Diseases

- 70% of your immune system is housed in the gut
- Probiotics and fermented foods increase the immune system within your gut
- The gut and your immune system have a symbiotic relationship
- A healthy gut flora increases the immune system

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