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Gut Microbiota Role in Depression
Ongoing research is showing a more distinct correlation between microorganisms in the gut and the development of mood disorders. A hallmark of depression is inflammation, which is caused by hyperactivity of microbiome alterations. In MDD individuals have been found to lack gut bacteria involved in regulating inflammation and immune functioning.
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References
Cheung SG, Goldenthal AR, Uhlemann A-C, Mann JJ, Miller JM and Sublette ME (2019) Systematic Review of Gut Microbiota and Major Depression. Front. Psychiatry 10:34. doi: 10.3389/fpsyt.2019.00034
Capuco, A., Urits, I., Hasoon, J., Chun, R., Gerald, B., Wang, J. K., Kassem, H., Ngo, A. L., Abd-Elsayed, A., Simopoulos, T., Kaye, A. D., & Viswanath, O. (2020). Current Perspectives on Gut Microbiome Dysbiosis and Depression. Advances in therapy, 37(4), 1328–1346. https://doi.org/10.1007/s12325-020-01272-7
Bastiaanssen, T. F. S., Cussotto, S., Claesson, M. J., Clarke, G., Dinan, T. G., & Cryan, J. F. (2020). Gutted! Unraveling the Role of the Microbiome in Major Depressive Disorder. Harvard review of psychiatry, 28(1), 26–39. https://doi.org/10.1097/HRP.0000000000000243
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