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How Phencyclidine Works and its Effect on the NMDA Receptor
PCP acts as a NMDA receptor antagonist by blocking the receptors central calcium channel. Through this, glutamate is prevented from having its usual effects. This is similar in other NMDA antagonists as well.
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Phencyclidine and Schizophrenia
How Phencyclidine Works and its Effect on the NMDA Receptor
A drug is administered that prevents the neurotransmitter glutamate from having its usual effects at a specific type of receptor. An individual who takes this drug experiences disorganized thoughts, emotional flatness, and a feeling of being disconnected from their own body and environment. Based on these effects, what is the most logical conclusion one can draw about the role of this neurotransmitter system?