Activation of these receptors in the bed nucleus of stria terminals causes anxiety reduction due to serotonin increase.

University of Vermont

Family	Type	Mechanism

5-HT1	Metabotropic	decreasing cellular levels of cAMP, 5-HT1A can be a           somatodendritic autoreceptor. 5-HT1B and 1D are terminal autoreceptors.

5-HT2	Metabotropic	Excitatory

5-HT3	Ionotropic	depolarizing plasma membrane- cation channel, quick action and quick desensitization.

5-HT4	Metabotropic	increasing cellular levels of cAMP

5-HT5A	Metabotropic	inhibiting adenylate cyclase activity.

5-HT7	Metabotropic	increasing cellular levels of cAMP


Serotonin Receptors

Serotonin Reference Library

5-HT1A Receptor

The 5-HT2 agonist mCPP is known to be anxiogenic, and facilitates the startle response when injected into the BNST, thus activation of 5-HT2 receptors in the bed nucleus increases anxiety


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