A type of post synaptic receptor that utilizes g-protein coupled signaling in order to cause intracellular changes

Metabotropic Receptor

"Ligand gated ion channels," that require a ligand to bind to the receptor in order to open the ion channels and allow ions into the cell. Typically, the ligand is a neurotransmitter and the ions that pass through the receptor are sodium, potassium, chloride, and/or calcium

Ionotropic Receptors

University of Vermont

Family	Type	Mechanism

5-HT1	Metabotropic	decreasing cellular levels of cAMP, 5-HT1A can be a           somatodendritic autoreceptor. 5-HT1B and 1D are terminal autoreceptors.

5-HT2	Metabotropic	Excitatory

5-HT3	Ionotropic	depolarizing plasma membrane- cation channel, quick action and quick desensitization.

5-HT4	Metabotropic	increasing cellular levels of cAMP

5-HT5A	Metabotropic	inhibiting adenylate cyclase activity.

5-HT7	Metabotropic	increasing cellular levels of cAMP


Serotonin Receptors

Breedlove, S. & Watson, N. (2017). Behavioral neuroscience, eighth edition. Oxford University Press.

Behavioral Neuroscience 8th Edition

Activation of these receptors in the bed nucleus of stria terminals causes anxiety reduction due to serotonin increase.

5-HT1A Receptor

The 5-HT2 agonist mCPP is known to be anxiogenic, and facilitates the startle response when injected into the BNST, thus activation of 5-HT2 receptors in the bed nucleus increases anxiety


Learn Before

Related

Learn After