The hypothesis of this article suggests that NRHypo (or NMDA receptor hypofunction) could be viewed as a model for a mechanism which could explain the natural course and symptoms of schizophrenia. NRHypo is a condition that is induced in the human/animal brain that is induced by an NMDA antagonist. This hypothesis implies that the disease may be coreelated with dysfunction of NMDA receptors or other downstream effects when NMDA receptors are blocked (one consequence of this occurring is the overwhelming release of Glu). This article proposes that the NRHypo model lacks the ability to cause psychotic symptoms in adolescents, as there are maturational changes in the brain that need to occur. After the circuitry of the brain has matured, the NRHypo state is able to trigger the entire spectrum of schizophrenia symptoms and clinical deterioration.