IL-6 cytokines bind to IL-6 receptors (IL-6Rs) on cell surfaces. The protein gp130 found within the receptor transmits the cytokine's signal and prompts janus kinases (JAKs) to come to the IL-6R. These kinases phosphorylate the receptor as well as themselves which ultimately leads to the phosphorylation and dimerization of the protein Stat3. Stat3 dimers move into the nucleus and bind to the IFNγ active site of genes related to inflammation and intracellular adhesion as a transcription factor.