Relation

Impact of Comorbidities and Glycemia at Admission and Dipeptidyl Peptidase 4 Inhibitors in Patients With Type 2 Diabetes With COVID-19: A Case Series From an Academic Hospital in Lombardy, Italy

  • The objective of this study was to evaluate the association between type 2 diabetes, plasma glucose levels, and antidiabetic medication on mortality rate in COVID-19 patients.

  • The data for this study was collected from a single center in Lombardy, Italy and involved 379 COVID-19 patients who were admitted between February 20th and April 9th of 2020.

  • 90 patients in the study had type 2 diabetes and it was found that the mortality rate in diabetic patients was double that of patients without diabetes.

  • Although after correcting for age and sex, type 2 diabetes was not found to be independently associated with risk of mortality.

  • Elevated levels of plasma glucose and IL-6 were independently associated with higher mortality rates.

  • The use of insulin and β-blockers as antidiabetic medicine were also associated with higher rates of mortality while the use of dipeptidyl peptidase 4 inhibitors was associated with lower mortality rates.

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Updated 2020-12-17

Tags

SARS-CoV-2 (COVID-19)

Biomedical Sciences