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Implications for herd immunity, antibody-based therapeutics, public health strategies, and vaccine development.

  • First, as infected people do not develop long-lasting protecting antibodies against SARS-CoV-2, the idea of immune certificate for recovered COVID-19 patients is invalid. This finding also raises concerns for reinfection, chronic infection, and validity of the herd immunity theory for SARS-CoV- 2.
  • Second, COVID-19 IgG antibodies as tested by the kits may simply serve as a sign of the infection status and might not be protective neutralizing antibodies. The utilization of convalescent serum from recovered COVID-19 patients in clinical settings48 would be questionable. Clinical trials on the efficacy of convalescent serum from recovered COVID-19 patients in treating COVID-19 cases were conducted in Wuhan. Their results will provide further evidence to help elucidate the role of COVID-19 IgG antibodies.
  • Third, as serum COVID-19 IgM/IgG level can become undetectable after recovery in patients with SARS-CoV-2 infections, COVID-19 IgM/IgG test will not be a reliable tool for the surveillance of past infections of SARS-CoV-2 in areas where the epidemic is over.
  • Finally, in our study, most of the healthcare providers without a confirmed COVID- 19 diagnosis have been exposed to the wild-type SARS-CoV-2 virus in a highly contagious environment. However, none of them developed long-lasting protective antibodies against SARS-CoV-2. These findings raise the concern if the inactivated virus, subunit, and recombinant vaccines currently under development will be able to induce effective immune protections against SARS-CoV-2.

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Updated 2020-07-24

Contributors are:

Maria Galaviz Huerta
Maria Galaviz Huerta
🏆 1

Who are from:

Northwestern University
Northwestern University
🏆 1

Tags

SARS-CoV-2 (COVID-19)

Biomedical Sciences

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