One of the known reactions of COVID-19 is their powerful immune response in defense of the virus. In fact, one of the most common issues in severe patients is organ failure due to the high levels of inflammatory mediators and the virus itself causing damage to the cells. The mediators would cause scarring, ischemic, and necrosis of organ tissues. Commonly the lungs, heart and kidneys fail during severe COVID-19 infections. There have also been significant differences in cytokine levels based on the severity of infection meaning there will be additional differences in drug toxicity between patients based on their disease severity.