Phillips, K. (2022, August 2). What is Trigeminal Neuralgia: Causes, Symptoms, Treatment Options. https://www.tmjtexas.com/trigeminal-neuralgia-guide

Reference about relationship between sleep and trigeminal neuralgia

Ferini-Strambi L. (2017). Neuropathic Pain and Sleep: A Review. Pain and therapy, 6(Suppl 1), 19–23. https://doi.org/10.1007/s40122-017-0089-y

Reference for Neuropathic Pain and Sleep

Costigan, M., Scholz, J., & Woolf, C. J. (2009). Neuropathic pain: a maladaptive response of the nervous system to damage. Annual review of neuroscience, 32, 1–32. https://doi.org/10.1146/annurev.neuro.051508.135531

What is Neuropathic Pain reference

Professional, C. C. M. (n.d.). Neuropathic pain. Cleveland Clinic. https://my.clevelandclinic.org/health/diseases/15833-neuropathic-pain

reference for What is Neuropathic Pain?


Pain that sustains after a peripheral nerve injury is called neuropathic pain, also known as neuralgia. After peripheral injuries, microglial cells surround the synapses between pain fibers and neurons in the dorsal horn of the spinal cord, releasing chemicals that make the dorsal horn neurons hyper-excitable. This leads to neural signaling of pain in the hypothalamus. 

Cases of neuropathic pain can be considered disagreeable examples of neural plasticity since the nervous system (either the spinal cord or the cortex) amplifies its response to the pain signal. 

• Phantom Limb Pain 

• Migraines 


Neuropathic Pain 

Occurs when the nervous system is not functioning correctly.
Neuropathic pain can be described as any change or obstruction to the function of any nerves.

What is Neuropathic Pain?

It is reported that the combination of extended chronic pain and insomnia may increase the risk of suicidal ideation in pain patients.

-The condition has been commonly referred to as "The Suicide Disease" as patients have reported that the constant and extremely painful nature of the episodes have led to hopelessness and despair, eventually culminating in suicidal ideation

Why Trigeminal Neuralgia is called "The Suicide Disease"

Thertus, K. (2021). The Psychological Impact and Management of Trigeminal Neuralgia. In: Abd-Elsayed, A. (eds) Trigeminal Nerve Pain. Springer, Cham. https://doi.org/10.1007/978-3-030-60687-9_21

Psychological Impact and Management of Trigeminal Neuralgia

Trigeminal Neuralgia Support Group. (n.d.). Stanford Health Care. https://stanfordhealthcare.org/events/trigeminal-neuralgia-support-group.html

Reference for Support for Trigeminal Neuralgia

Navigating trigeminal neuralgia, its pain, and the often alienating effects of its pain can be extremely difficult, and so many groups and healthcare providers- like Stanford Healthcare- have formed support groups and other programs to help those diagnosed.

Support for those with Trigeminal Neuralgia

Wu, T., Hu, L., Lu, T., Chen, P., Chen, H., Shen, C. C., & Wen, C. (2015). Risk of psychiatric disorders following trigeminal neuralgia: a nationwide population-based retrospective cohort study. Journal of Headache and Pain, 16(1). https://doi.org/10.1186/s10194-015-0548-y

Reference for risk of psychiatric disorders following Trigeminal neuralgia

Allsop, M. J., Twiddy, M., Grant, H., Czoski-Murray, C., Mon-Williams, M., Mushtaq, F., Phillips, N., Zakrzewska, J. M., & Pavitt, S. (2015). Diagnosis, medication, and surgical management for patients with trigeminal neuralgia: a qualitative study. Acta neurochirurgica, 157(11), 1925–1933. https://doi.org/10.1007/s00701-015-2515-4

"Diagnosis, medication, and surgical management for patients with trigeminal neuralgia: a qualitative study" Reference

According to one report, when patients with trigeminal neuralgia reported themes that they struggled with, the four most common were "diagnosis and support with TN, living in fear of TN pain, isolation and social withdrawal, and medication burden and looking for a cure" (Allsop et al., 2015).

Importance of Support for Those woth Trigeminal Neuralgia

-One group conducted a nationwide retrospective cohort study "to explore the relationship between TN and the subsequent development of psychiatric disorders," and what they found was that "the most common subsequent psychiatric illnesses among the patients with TN were depressive disorder in 73 patients (2.23 %), anxiety disorder in 59 patients (1.80 %), and sleep disorder in 40 patients (1.22 %)" (Wu et al., 2015).

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