Costigan, M., Scholz, J., & Woolf, C. J. (2009). Neuropathic pain: a maladaptive response of the nervous system to damage. Annual review of neuroscience, 32, 1–32. https://doi.org/10.1146/annurev.neuro.051508.135531

It is reported that the combination of extended chronic pain and insomnia may increase the risk of suicidal ideation in pain patients.

Insomnia and Trigeminal Neuralgia

Phillips, K. (2022, August 2). What is Trigeminal Neuralgia: Causes, Symptoms, Treatment Options. https://www.tmjtexas.com/trigeminal-neuralgia-guide

Reference about relationship between sleep and trigeminal neuralgia

Ferini-Strambi L. (2017). Neuropathic Pain and Sleep: A Review. Pain and therapy, 6(Suppl 1), 19–23. https://doi.org/10.1007/s40122-017-0089-y

Reference for Neuropathic Pain and Sleep

What is Neuropathic Pain reference

Professional, C. C. M. (n.d.). Neuropathic pain. Cleveland Clinic. https://my.clevelandclinic.org/health/diseases/15833-neuropathic-pain

reference for What is Neuropathic Pain?


Pain that sustains after a peripheral nerve injury is called neuropathic pain, also known as neuralgia. After peripheral injuries, microglial cells surround the synapses between pain fibers and neurons in the dorsal horn of the spinal cord, releasing chemicals that make the dorsal horn neurons hyper-excitable. This leads to neural signaling of pain in the hypothalamus. 

Cases of neuropathic pain can be considered disagreeable examples of neural plasticity since the nervous system (either the spinal cord or the cortex) amplifies its response to the pain signal. 

• Phantom Limb Pain 

• Migraines 


Neuropathic Pain 

Occurs when the nervous system is not functioning correctly.
Neuropathic pain can be described as any change or obstruction to the function of any nerves.

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