The IL-6 family of cytokines are primary produced by T helper cells, macrophages, and fibroblasts to target activated B cells and plasma cells.  These molecules promote the differentiation of plasma cells and to stimulate IgG production.  Members of this family include:

- IL-6
- IL-11
- IL-31
- CNTF
- CT-1
- LIF
- OPN
- OSM

IL-6 Family

The IL-1 family of cytokines is primarily produced by macrophages, B cells, and dendritic cells.  These molecules target other B cells, natural killer (NK) cells, and T cells to promote a fever-like pyrogenic response, inflammation, and cell development - especially in bone marrow.  Members of this family include:

- IL-1α
- IL-1β
- IL-1ra
- IL-18
- IL-33
- IL-36α
- IL-36β
- IL-36γ
- IL-36Ra
- IL-37
- IL-1Hy2

IL-1 Family

Michigan State University

- interleukins (IL)
- tumor necrosis factors (TNF)
- interferons (IFN)
- colony stimulating factors (CSF)

Cytokine Categorization

Turner, M. D., Nedjai, B., Hurst, T., & Pennington, D. J. (2014). Cytokines and chemokines: at the crossroads of cell signalling and inflammatory disease. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 1843(11), 2563-2582.
https://www.sciencedirect.com/science/article/pii/S0167488914001967
doi: 10.1016/j.bbamcr.2014.05.014

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