While a majority of COVID-19-related strokes have been ischemic, a few have been intercranial hemorrhage, although the causes of the latter are not yet understood. One potential explanation is that SARS-Cov2 binds to and downregulates ACE2, slowing the conversion of angiotensin II to angiotensin, and that since higher levels of angiotensin II are associated with vasoconstriction, this causes blood vessels in the brain to rupture. ACE2 polymorphism may explain the increased risk of intracranial hemorrhage among the East Asian population.