For patients with cardiovascular, kidney or blood pressure problems, even a low dose of licorice can have toxic side effects.

Santa Clara University

Taking licorice for a prolonged period of time can result in harmful effects, and those considering taking licorice to strengthen their immune system should consult their doctors first. Less side effects have been reported with licorice that is taken orally compared to intravenously or intraperitoneally. For certain groups of people, even a small amount of licorice can be harmful. 

Harmful side effects of licorice  

Yang, F., Zhang, Y., Tariq, A., Jiang, X., Ahmed, Z., Zhihao, Z., Idrees, M., Azizullah, A., Adnan, M., & Bussmann, R. W. (2020). Food as medicine: A possible preventive measure against coronavirus disease (COVID-19). Phytotherapy research : PTR, 10.1002/ptr.6770. Advance online publication. https://doi.org/10.1002/ptr.6770

Food as medicine: A possible preventive measure against coronavirus disease (COVID-19)

Some studies have reported hypertension as an effect of glycyrrhizin and licorice consumption.

Hypertension as a side effect of licorice consumption 

Licorice and glycyrrhizin intake can be dangerous for patients with certain comorbidities

It was found that for pregnant women and breast-feeding children, a daily intake of a low dose of licorice can cause serious health complications. 

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