- cold chain
- risk of viral transmission
- risk of reversion to pathogenic form
- reactivation in immunocompromised individuals
- recombination with related viruses circulating in the population
-people with suppressed immune systems majority of the time cannot get live vaccines

Disadvantages to live-attenuated vaccines

- Codagenix Incorporation’s proprietary deoptimized SARS-CoV-2 vaccine candidate (most prominent)
- A single-dose live-attenuated YF17D-vectored SARS-CoV2 vaccine candidate

Live-attenuated SARS-CoV-2 vaccines 

Live-attenuated vaccines (LAVs) are live, reproducing, yet mild viruses. The designs are meant to produce single-dose immunity without illness. 


Syracuse University

Virus vaccines use the virus itself, or  in a weakened or inactive form.

Virus Vaccines for COVID-19

Shin, M.D., Shukla, S., Chung, Y.H. et al. COVID-19 vaccine development and a potential nanomaterial path forward. Nat. Nanotechnol. 15, 646–655 (2020). doi: 10.1038/s41565-020-0737-y

https://doi.org/10.1038/s41565-020-0737-y

COVID-19 vaccine development and a potential
nanomaterial path forward

Information gained from studies done on both the immune response and vaccine development to related betacoronaviruses can help us gain insight on the immunopathology of SARS-CoV-2 and guide the devlopment of a vaccine. 

Vaccine Development for SARS-CoV-2 Based on Knowledge Gained from SARS-CoV and MERS-CoV

Live-attenuated vaccines

IVs are pathogens (or fractions thereof) that have been inactivated by heat or chemical reaction

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