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Methylation: The Effect of Experience on Gene Expression as seen in rats

The level of attentivness in mothers negatively correlated to the stress level found in child rates in addition to negatively correlating with the methylation levels of the glucocorticoid receptor.

  • Rat mothers that showed low levels of licking and grooming their pups lead to pups with a methylation of the gene for the glucocorticoid receptor, which is responsible for responding to stress.

  • Inattentive mothers reduces expression of this gene in pups, which in turn makes the pups secrete more glucocorticoids in response to stress.

  • Oversecretion of glucocorticoids in rat pups leads to hyperresponsiveness to stress in adult life.

  • Rat mothers that showed high levels of licking and grooming their pups prevent the methylation of the stress hormone receptor gene in their pups

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Updated 2021-08-14

Tags

Behavioral Neuroscience

Psychology

Neuroscience (Neurobiology)

Social Science

Empirical Science

Science

Life Science / Biology

Biomedical Sciences