MVC is a popular software architecture pattern used in web applications to separate application logic and presentation. In Laravel, MVC architecture is used to structure the codebase. The "Model" manages data and database interaction, the "View" renders the user interface, and the "Controller" handles business logic and communication between the Model and View. In Laravel, the Model defines database tables and relationships, the View is a Blade template, and the Controller processes user requests interact with the Model, and passes data to the View. Using MVC in Laravel improves code organization, maintainability, and testability while following the Single Responsibility Principle.