1Cademy - Motor Neuron Destruction and Death/ Motor Impairment

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Motor Neuron Destruction and Death/ Motor Impairment

Virus caused destruction of motor neurons in the spinal cord, or even the cranial motor neurons in the brain stem (such as poliovirus) can cause atrophy of the muscles which no longer receive input from the neurons
This may necessitate a ventilator if the muscles controlling breathing are targeted
In amyotrophic lateral sclerosis (ALS) there is spontaneous death of motor neurons in the brainstem and spinal cord, causing the affected muscles to "waste away"
ALS causes increasingly worse paralysis, eventual loss of skeletal muscle function, and typically a premature death

Updated 2021-08-06

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