This gene codes for a protein that is important in DNA methylation/demethylation processes.  The frequencies of MTHFR rs1801131 C, MTR rs1805087 G and MTRR rs1801394 G alleles (probably associated with a reduced DNA methylation capacity) are significantly higher in athletes compared to nonathletes.

Michigan State University

The following short sequences of DNA have been used to identify chromosomes that are  encoding factors that control gene expression by rearrangement of chromatin fibers and mRNA stability in elite power athletes:
- MTHFR
- RC3H1
- ZNF423
- MED4
- WAPL

Genetic Markers that Indicate Encoding Factors that Control Gene Expression by Rearrangement of Chromatin Fibers and mRNA Stability in Athletes

Maciejewska-Skrendo, A., Cięszczyk, P., Chycki, J., Sawczuk, M., & Smółka, W. (2019). Genetic Markers Associated with Power Athlete Status. Journal of human kinetics, 68, 17–36. https://doi.org/10.2478/hukin-2019-0053

Genetic Markers Associated with Power Athlete Status (Reference)

MTHFR

Gene expression regulation is also mediated through mRNA translation regulation and stability, and RD3H1 encodes a protein that is important to this process. The RC3H1 rs767053 G allele is a marker for power performance in athletes.

RC3H1

This gene encodes a protein that functions as a DNA-binding transcription factor in multiple signaling pathways. ZNF423 rs11865138 C allele is described as a marker of power athlete status.

ZNF423

The MED4 gene encodes a protein that is important for activating nuclear receptors in a ligand-dependent manner. The MED4 gene (location: 13q14.2) rs7337521 T allele is associated with elite strength athlete status.

MED4

The WAPL protein promotes sister-chromatid resolution in mitotic prophase.  The WAPL Gene (location: 10q23.2) rs4934207 C allele was associated with elite strength athlete status.

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