*Mycoplasma genitalium* antigens are highly variable which allows them to evade the host immune system response. The membrane proteins in *M. genitalium* also are responsible for causing host inflammation and immune response.

Virulence factors of *Mycoplasma genitalium*

Often people with nongonococcal urethritis are asymptomatic and do not know they carry the disease. But common symptoms are: 
- purulent discharge
- dysuria

When left untreated, nongonococcal urethritis can cause:
- Pelvic inflammatory disease
- salpingitis
- epididymitis
- prostatitis

Signs and symptoms of nongonococcal urethritis

*Mycoplasma genitalium* is commonly found in microbiota in healthy people but can cause urethritis or vaginitis. it has been recorded to cause 20%-25% of nonchlamydial Nongonococcal urethritis cases. 

University of Wisconsin - Madison

- *Chlamydia trachomatis*
- *Mycoplasma genitalium*
- *Ureaplasma urealyticum*
- *Mycoplasma hominis*

Pathogens causing Nongonococcal urethritis

https://openstax.org/details/books/microbiology/

Microbiology covers the scope and sequence requirements for a single-semester microbiology course for non-majors. The book presents the core concepts of microbiology with a focus on applications for careers in allied health. The pedagogical features of the text make the material interesting and accessible while maintaining the career-application focus and scientific rigor inherent in the subject matter. Microbiology’s art program enhances students’ understanding of concepts through clear and effective illustrations, diagrams, and photographs.

Microbiology is produced through a collaborative publishing agreement between OpenStax and the American Society for Microbiology Press. The book aligns with the curriculum guidelines of the American Society for Microbiology.

OpenStax Microbiology Textbook

*Chlamydia trachomatis* can cause Nongonococcal urethritis. It also causes one of the most commonly diagnosed sexually transmitted infections, Chlamydia.  This bacterium can also cause an ocular disease, trachoma. The life cycle of *C. trachomatis* is shown below.

*Chlamydia trachomatis*

*Mycoplasma genitalium*

*Ureaplasma urealyticum* can be found in a normal healthy microbiota. However, it can cause urethritis. 

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