- isolated antibody showed high potent neutralizing activity against SARS-CoV-2
- NAb 4A8 binding can not block interaction between hACE2 and spike protein

State University of New York at Stony Brook

NTD targeting NAbs show high potency but the exact mechanism is still unclear
- NAb 4A8
- NAb 7D10

NAbs targeting NTD of spike protein

Huang, Y., Sun, H., Yu, H., Li, S., Zheng, Q., & Xia, N. (2020). Neutralizing antibodies against SARS-CoV-2: current understanding, challenge and perspective. Antibody Therapeutics, 3(4), 285-299.
https://doi.org/10.1093/abt/tbaa028

Neutralizing antibodies against SARS-CoV-2: current understanding, challenge and perspective 

NAb 4A8

- can inhibit binding of S protein to cell receptor DPP4

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