- isolated antibody showed high potent neutralizing activity against SARS-CoV-2
- NAb 4A8 binding can not block interaction between hACE2 and spike protein

NAb 4A8

- can inhibit binding of S protein to cell receptor DPP4

NAb 7D10

NTD targeting NAbs show high potency but the exact mechanism is still unclear
- NAb 4A8
- NAb 7D10

State University of New York at Stony Brook

- NAbs targeting NTD of spike protein
- NAbs targeting S2 subunit of spike protein

Non-RBD Targeted Antibodies

Huang, Y., Sun, H., Yu, H., Li, S., Zheng, Q., & Xia, N. (2020). Neutralizing antibodies against SARS-CoV-2: current understanding, challenge and perspective. Antibody Therapeutics, 3(4), 285-299.
https://doi.org/10.1093/abt/tbaa028

Neutralizing antibodies against SARS-CoV-2: current understanding, challenge and perspective 

NAbs targeting NTD of spike protein

have rarely been reported, but since S2 subunit is more sequentially conserved, it might be helpful to screen for broad S2 specific NAbs
- mAb 1A9

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