- was generated by immunization with SARS-CoV antigen
- proved to react with SARS-CoV-2 S2 subunit, but has no neutralizing activity against SARS-CoV-2 virus

mAb 1A9

have rarely been reported, but since S2 subunit is more sequentially conserved, it might be helpful to screen for broad S2 specific NAbs
- mAb 1A9

State University of New York at Stony Brook

- NAbs targeting NTD of spike protein
- NAbs targeting S2 subunit of spike protein

Non-RBD Targeted Antibodies

Huang, Y., Sun, H., Yu, H., Li, S., Zheng, Q., & Xia, N. (2020). Neutralizing antibodies against SARS-CoV-2: current understanding, challenge and perspective. Antibody Therapeutics, 3(4), 285-299.
https://doi.org/10.1093/abt/tbaa028

Neutralizing antibodies against SARS-CoV-2: current understanding, challenge and perspective 

NTD targeting NAbs show high potency but the exact mechanism is still unclear
- NAb 4A8
- NAb 7D10

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