After 12 weeks of administering nefazodone to patients with major depressive disorder (MDD) and that had reported forms of childhood trauma, the effects of this antidepressant alone was not more effective than psychotherapy alone. Moreover, only 32.9% of patients with MDD and reported childhood trauma achieved remission of depression with the antidepressant alone after the study.

Nefazodone's efficacy on Major Depressive Disorder in patients with childhood trauma

After 12 weeks of administering nefazodone to patients with major depressive disorder (MDD) and no reported childhood trauma, the effects of nefazodone (without psychotherapy) was approximately equal to the effects of CBASP (without the antidepressant). 

University of Illinois at Chicago

An antidepressant used to treat depression. 

Nefazodone (Antidepressant)

Nemeroff, C. B., Heim, C. M., Thase, M. E., Klein, D. N., Rush, A. J., Schatzberg, A. F., ... & Keller, M. B. (2003). Differential responses to psychotherapy versus pharmacotherapy in patients with chronic forms of major depression and childhood trauma. Proceedings of the National Academy of Sciences, 100(24), 14293-14296.

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