- Severe head injury
- Cerebrovascular disease
- Diabetes
- Obesity

Michigan State University

- ~1% of patients have early-onset AD due to inheriting autosomal dominant mutations in genes whose protein products are involved in the production of AB peptides.
- Genetic risk factor for more common form of AD is the APOE ε4 gene which encodes the apoE4 lipid carrier
- Greater than 60% of caucasian patients with AD carry at least one APOE ε4 gene

Can Alzheimer's Disease be inherited?

Mucke, L. Alzheimer's disease. Nature 461, 895–897 (2009). https://doi-org.proxy2.cl.msu.edu/10.1038/461895a

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