Tulane University

Several vaccines for neglected tropical diseases are in clinical phases of development or early research. The collaboration between university laboratories, product development partnerships and public-sector manufacturers has promoted vaccine construction and manufacturing. Human vaccines for hookworm infections are currently entering Phase II clinical trials. Vaccines for Chagas disease, food-borne trematode infections and onchocerciasis are in a preclinical phase of development. 

Multinational Collaborations that Support Vaccine Development

Hotez, P. (2011). A handful of ‘antipoverty’ vaccines exist for neglected diseases, but the world’s poorest billion people need more. Health Affairs, 30(6), 1080-1087. doi:10.1377/hlthaff.2011.0317

A Handful Of ‘Antipoverty’ Vaccines Exist For Neglected Diseases, But The World’s Poorest Billion People Need More

This nonprofit organization is located at Texas Children’s Hospital and Baylor College of Medicine in Houston, Texas. The Sabin Institute’s primary goal is to manufacture vaccines for NTDs that have been deprioritized or underfunded by national governments and pharmaceutical companies. Within the laboratory, Sabin researchers hope to understand the intricacies of parasites, viruses and bacteria to isolate vaccine antigens. The resulting technology is sent to contract organizations that will efficiently manufacture and distribute the vaccine. Sabin collaborates with public-sector vaccine manufacturers in Brazil, Mexico and other regions of Latin America. 

Sabin Vaccine Institute

The Infectious Disease Research Institute has partnered with the Instituto Butantan to develop a human vaccine for leishmaniasis that can also be used for veterinary purposes. Financing of this research is supported by the Bill & Melinda Gates Foundation, Carlos Slim Institute of Health and other donations. Additionally, the Brazilian government has significant contributions to promote the production and clinical research of these vaccines. 

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