SARS-CoV-2 binds to the human angiotensin-converting enzyme 2 (ACE2) receptor that is expressed in the lungs, heart and vascular endothelium. This association may trigger an inflammatory response that could lead to myocardial injury and dysfunction. The immunogenic effects of infection by SARS-CoV-2 may result in the progression of CD. The burden of Chagas Disease is dependent on parasitic load and host factors, such as genetic susceptibility strength of the immune system. Covid-19 may trigger reactivation of CD in the indeterminate phase due to disease-induced immunosuppression. The primary concern is that the immunological and physiological effects of Covid-19 may increase parasitic load by depressing the immune system, triggering reactivation of Chagas Disease. This potential reactivation may be caused by a cytokine storm, therapeutics used to treat Covid-19 or the virus itself.