COVID-19 infection was confirmed by PCR from nasal swabs. One patient was confirmed to be positive for COVID-19 on a routine surveillance swab but remained asymptomatic over the course of the study. Most presented with respiratory symptoms, while those categorized with other presentations included 4 young patients with serious comorbidities. Significant comorbidities were prevalent in this pediatric cohort, with 24 patients (50%) having 1 comorbidity, 8 (17%) with 2, and 9 (19%) with 3 or more significant comorbidities.

On admission, 33 (69%) were severely or critically ill, 12 (25%) required vasoactive drugs, and, while single organ failure (respiratory) affected most, 11 (23%) experienced failure of 2 or more organ systems. A total of 39 patients (81%) required respiratory support that exceeded their baseline, of whom 21 (44%) were managed noninvasively. The remaining 18 patients (38%) required endotracheal or tracheostomy ventilation. Adjunctive ventilatory interventions or extracorporeal therapies were required in 6 children (13%). Continuous renal replacement therapy was not required in the pediatric cohort.