Due to unwanted symptoms, such as excess body and facial hair, obesity and excess adipose tissue concentrated in the midsection, male patterned baldness, painful cystic acne, and irregular menstruation, many people with PCOS develop poor self-esteem and body image. Common psychiatric comorbidities include depression, anxiety, OCD, body dysmorphic disorder, borderline personality disorder, and more.

Women with PCOS are 4 times more likely to attempt suicide than women without PCOS.