Processes like up-regulation and down-regulation (see "Agonist" and "Antagonist") are evidence of the plasticity of receptors in the brain (i.e., the fact that each subtype of neurotransmitter receptor can vary in number and distribution in the brain). Receptor plasticity occurs during development and throughout adulthood. Therefore, a neuron's sensitivity to different transmitters can vary throughout the lifespan. 

Receptor Plasticity

Plasticity of the sensory cortex refers to a characteristic of the cortex, that the cortical maps can change with experience. This was demonstrated in an experiment by Merzenich and Jenkins (1993), where they surgically removed the middle finger of the monkey, then found later that the region of cortex that responded to each remaining, adjacent finger expanded.

Plasticity of the Sensory Cortex

The nervous system's capacity to change and adapt is known as neuroplasticity. This adaptation can be triggered by various factors, such as personal experiences, normal developmental stages, or in response to damage or injury. The underlying mechanisms of neuroplasticity include the formation of new synapses, the elimination of unused ones, modifications in glial cells, and even the generation of new neurons. While the brain's plasticity is at its peak during early life, it retains a significant capacity for change and reorganization throughout adulthood.

Neuroplasticity

Infants have diverse hearing capbilities in early life. If that hearing ability isn't used, for example if they have damage or deformity in their ears, their ability to distinguish or interpret sounds disappears. 

Musicians show higher sensitivity and activation to musical notes, with bigger differences in brain imaging if the musician was trained from an early age.

Plasticity, auditory perception and auditory pathways

Studies utilizing Art Therapy  as part of a treatment for brain diseases or injuries can lead to promotion in brain plasticity

Mindfulness Based Art Therapy for Individuals with Traumatic Brain Injuries and other Brain Diseases

One example of culture’s influence on brain function involves the use of the abacus in East Asian cultures. Giyoo Hatano, a Japanese developmental psychologist, hypothesized that abacus users relied on a mental representation of an abacus to solve arithmetic problems. In an fMRI study, Japanese participants, all of whom were familiar with the abacus, demonstrated increased activation in the parietal lobe. The magnitude of activation was positively correlated with the difficulty of the arithmetic problem. By contrast, individuals with no abacus experience tend to engage brain regions associated with linguistic processing when tasked with arithmetic problems (i.e. Broca’s area, Wernicke’s area). These findings support Hatano’s theory and illustrate the influence of culture on neuroplasticity.

Cultural neuroscience and arithmetic processing

A significant example of cultural neuroplasticity involves the famous “taxi driver” study by Maguire et al. (2000). They used structural MRI to compare the brains of experienced London taxi drivers to controls who did not drive taxis. Taxi drivers had larger posterior hippocampi, but smaller anterior hippocampi, compared to controls. Posterior and anterior hippocampal volume was positively and negatively correlated, respectively, with time spent as a licensed taxi driver. These findings support the hypotheses that a) the posterior hippocampus is involved in spatial/navigational memory and b) environmental stimuli can essentially “reshape” the brain.

Cultural neuroscience and spatial navigation

Plasticity is how the brain is able to learn and adapt to environments. It exists throughout a person's lifetime, though it tends to be more active in early development when the brain is still forming. Plasticity is one of the key concepts within behavioral neuroscience that affects nearly all systems of the brain and brain functions.

Grinnell College

California Polytechnic State University, San Luis Obispo

- Evolution of the Brain and Behavior
- Life-Span Development of the Brain and Behavior

Evolution and Development of the Nervous System

Breedlove, S. & Watson, N. (2017). Behavioral neuroscience, eighth edition. Oxford University Press.

Behavioral Neuroscience 8th Edition

Plasticity

The brain is a highly complex organ that develops in an orderly fashion, as directed by genes and the environment. There are four main stages of brain development that describe how the brain changes in morphology throughout prenatal life. Within these four main stages of brain morphological development, there are six stages describing the development of the nervous system that enable the brain to change in morphology. (Page 194 has images of the morphological changes of the developing brain). 

Stages of Brain Development

Experience and the environment regulate gene expression in brain development by helping to shape behaviors and a person's surroundings and vice versa. This is called epigenetics.

Genes and Experience Guide Brain Development

- visual deprivation

- early exposure to visual patterns

Individual Differences in Experience Affect Brain Development 

- Memory Impairment

- Alzheimer's Disease 


Brain Changes Due to Aging

The process in which physical/behavioral changes of a population occur over long periods of time. Evolution is a scientific theory that for over the last 150 years, scientists have gathered an overwhelming amount of evidence that supports this theory.  

Evolution 

- Development begins from common structure (dorsal tube)
- Symmetry within brain structures (bilateral symmetry) 
- Construction of spinal nerves with spinal cord (segmentation)
- Communication between brain and spinal cord (hierarchical control) 
- Differentiated neural systems 
- Localized functions

Common Neural Features in Vertebrates

Abnormalities in the development of the nervous system that are influenced by both our genes and the environment. Developmental disorders commonly manifest as behavioral abnormalities.

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