Pompholyx (dyshidrotic eczema) from personal protective equipment (PPE) is caused by occlusion from prolonged glove or rubber boot wear. It leads to symmetrically occurring small blisters on the hands or feet that may itch, tingle, or burn. To prevent pompholyx, apply emollients before donning gloves or rubber boots. To treat an existing skin rash, topically apply mid‐strength or potent glucocorticoids.