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Potential use of polyphenols in the battle against COVID-19
- Many naturally occurring polyphenols are inexpensive to produce and have low risk for development of toxicity, making these compounds good candidates for preventive treatment to decrease viral infectivity and to dampen the risk of a virus-induced inflammatory storm.
- At the molecular level, polyphenols hold promise as inhibitors of viral proteases involved in viral replication due to their general affinity to proteins via hydrogen bonding and their low risk of toxic effects.
- The same may hold true for binding of polyphenols to S protein, although pre-clinical and clinical studies are required to strengthen existing evidence. Another point that should be taken into account is the proper formulation for these polyphenol-based nutraceuticals.
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Updated 2021-03-05
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SARS-CoV-2 (COVID-19)
Biomedical Sciences