- Transcription is stopped at termination sites usually they contain “AT” repeats and the AG region that is palindromic and has AT's after. Because of this, the RNA transcription (product) can form a hair pin. 
- This hairpin causes an RNA polymerase to pause and likely causes a conformation change in RNA polymerase that causes it to release from the DNA. – but studies suggest this is a multi step process.
- Rho factor – some termination sites lack the similarities described above – the Rho factor terminates those sequences – it is a helicase that unwinds RNA, DNA and RNA double helices. It attaches to RNA and travels until it finds RNA polymerase that is paused and it pushes RNA polymerase that causes rebinding of DNA which ends transcription. 


Grand Valley State University

- Transcription processed 5’ -> 3’ 
- In bacteria, transcription and translation occur nearly simultaneously because of the absence of the nucleus. These are typically the house keeping genes that are continually expressed.


Prokaryotic RNA Transcription (Elongation)

Voet, D., Voet, J. G., & Pratt, C. W. (2013). Chapter 26: Transcription and RNA Processing. In Fundamentals of biochemistry: Life at the molecular level (4th ed., pp. 919-957). Hoboken, NJ: Wiley. Retrieved April 4, 2021, from archive.org.

Learn Before

Related