Individuals with anti-NMDA encephalitis manifest significant psychiatric symptoms like psychosis early in the disease timeline. Evidence with this disease correlates with the glutamatergic model of schizophrenia, and contributes to the research on schizophrenic neural circuit dysfunction. Psychotic symptoms in anti-NMDAR encephalitis has been a topic of interest, as it questions whether it is an identifiable, treatable subtype of psychosis. There is a distinct relation between schizophrenia and autoimmunity disturbances. There is a lack of evidence for autoantibodies that may result in psychosis, however autoimmunity involving IgG GluN1 antibodies causes a state similar to schizophrenia.