This creates a pore that allows for moving alpha43 to the surface. Alpha43 moves to the surface to signal flocculation. 

Grand Valley State University

Antigen 43 has an alpha43 subunit and a beta43 subunit. Beta43 is the beta barrel subunit. 

Beta barrel proposed structure: alternating hydrophobic and hydrophilic sections on beta sheets that they had observed. There are 18 sheets of them with shorter external loops. 

Structure of Antigen 43

Henderson, I. R., & Owen, P. (1999). The major phase-variable outer membrane protein of Escherichia coli structurally resembles the immunoglobulin A1 protease class of exported protein and is regulated by a novel mechanism involving Dam and oxyR. Journal of bacteriology, 181(7), 2132–2141. https://doi.org/10.1128/JB.181.7.2132-2141.1999



The Major Phase-Variable Outer Membrane Protein of Escherichia coli Structurally Resembles the Immunoglobulin A1 Protease Class of Exported Protein and Is Regulated by a Novel Mechanism Involving Dam and OxyR


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