The prepulse inhibition (PPI) of the acoustic SR (ASR) is a measurement of sensorimotor gating and information-processing deficits in neuropsychiatric disorders like schizophrenia. PPI is a reduced startle response to a strong sensory stimulus when the stimulus follows a barely noticeable stimulus. PPI is similar in human and experimental animal models. Deficits in PPI can be produced in rodents by analyzing and initiating psychotomimetics such as dopaminergic and serotonergic agonists and glutamatergic antagonists. Furthermore, dopaminergic stabilizers have been shown to restore social behavior in a rat model of schizophrenia, and regulatory feedback loops exist among serotonergic, GABAergic, and dopaminergic neurotransmitters. For example, interactions between accumbal dopamine and various non-dopamine receptors, such as N-methyl-d-aspartate (NMDA)-, AMPA-, GABA (A)-, and nicotinic-receptors were reported in a rodent model of schizophrenia .Social isolation rearing in rats, which is a valid neurodevelopmental model of schizophrenia, reduces dopamine levels in the frontal cortex.