The significant loss of multiple brain regions results in a dramatic loss in brain functionality. Additionally, the heightened function of the amygdala and lack of function in the frontal lobe results in a major change in the behavior of C-PTSD patients. 

Functional changes C-PTSD patients as a result of volume loss

People with C-PTSD lose volume of  their hippocampal cortex and anterior cingulate cortex (ACC). These areas of the brain are responsible for a majority of our natural emotional functions. 

Wayne State University

Meta analysis has proved several drastic anatomical changes in the brains of C-PTSD patients.

Anatomical Brain changes 

Reduction in hippocampal cortex and anterior cingulate cortex

The visual below shows the dramatic difference in frontal lobe volume in a normal vs C-PTSD patient

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