1. Wang, X., Xia, Y., Yan, R., Sun, H., Huang, Y., Zou, H., Du, Y., Hua, L., Tang, H., Zhou, H., Yao, Z., & Lu, Q. (2023). The sex differences in anhedonia in major depressive disorder: A resting-state fmri study. Journal of Affective Disorders, 340, 555–566. https://doi.org/10.1016/j.jad.2023.08.083

Claremont McKenna College

Anhedonia is the inability to feel pleasure. Individuals with this symptom show little interest in activities that are typically considered enjoyable, such as hobbies, recreational pursuits, or sexual relations.

Anhedonia

Read the following clinical vignette. Based on the information provided, identify the specific symptom being described and justify your answer by linking the individual's statements to the definition of the symptom.

Symptom Identification from a Clinical Vignette

Researchers conducted a study using fMRI with the purpose of identifying any potential brain activity differences in male and female patients with anhedonia. The study featured three different groups of participants: 281 MDD patients with severe anhedonia, 133 MDD patients with low anhedonia, and 213 healthy individuals. The study results reflected clear differences, as the bilateral insula, right hippocampus, right post cingulum cortex, and left putamen experienced notable differences in activity depending on gender.

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