Bipolar disorder is a mood disorder that causes those impacted to shift back and forth between depression and mania.

Bipolar Disorder

Metabolic disorders are conditions that disrupt normal metabolism, the process of converting food to energy. These disorders often involve problems with how the body responds to/produces insulin, can impair glucose metabolism, and increases the risk of other health complications. 

Metabolic Disorders

Metabolic disorders are approximately three times more prevalent in individuals with bipolar disorder than in the general population.


Comorbidity Rate Bipolar Disorder and Metabolic Disorders

Arizona State University

Bipolar disorder is frequently accompanied by metabolic disorders, which are conditions that worsen psychiatric symptoms and treatment outcomes but are often overlooked in psychiatric care. Recent research suggests a bidirectional relationship via biological pathways including insulin signaling and energy metabolism. The article calls for a paradigm shift towards personalized, multidisciplinary care models that incorporate metabolic assessments.

The Overlooked Role of Metabolic Disorders in Bipolar Disorder

Anouar Khayachi, Abraham Nunes, Martin Alda, Guy A. Rouleau,
The overlooked role of metabolic disorders in bipolar disorder,
Neuroscience & Biobehavioral Reviews,
Volume 174,
2025,
106203,
ISSN 0149-7634,
https://doi.org/10.1016/j.neubiorev.2025.106203.

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