"The mean time to stay in the hospital was significantly
lower in IVM group compared with the controls (7.62 ± 2.75 versus 13.22 ±5.90 days, p=0.00005,
effect size= 0.82)."

Northwestern University

Ivermectin+Azithromycin+Hydroxychloroquine treatment was shown to result in a better cure rate and shorter hospital stay compared to control.
- groups used
- results demonstrating better cure rate
- results demonstrating shorter hospital stay
- important considerations

Ivermectin+Azithromycin+Hydroxychloroquine Treatment for COVID-19

Gorial F. I., Mashhadani S., et al. Effectiveness of Ivermectin as add-on Therapy in COVID-19 Management (Pilot Trial). Published online July 8, 2020.  https://doi.org/10.1101/2020.07.07.20145979 

Effectiveness of Ivermectin as add-on Therapy in COVID-19 Management (Pilot Trial)

"Of 87 patients included in the study, the mean age ± SD (range) of patients in the IVM
group was similar to controls [44.87 ± 10.64 (28-60) vs 45.23 ± 18.47 (8-80) years, p=0.78]"

Groups Used in Study

Results demonstrating shorter hospital stay

"All the patients of IVM group were cured compared with the controls [ 16 (100 %) vs 69 (97.2
%)]. Two patients died in the controls. Majority of patients in both groups were male but statistically not significant [11(69%) versus 52
(73%), with male: female ratio 2.21 versus 2.7-, p=0.72)."

Results demonstrating improved cure rate

Important to conduct another larger follow up study in order to validate these results since they may not be entirely conclusive due to unknown confounders. A "national multicenter randomized study" is planned to be performed in Iraq with IVM. along since HCQ is being withdrawn as therapy according to WHO advice.

Important Considerations and Implications

- A majority of the COVID-19 virus in a person is killed in 2 days with ivermectin
- Avermectin --> Ivermectin
- When avermectin is converted into ivermectin. a double bond between two carbon atoms in a benzene ring becomes a single bond
- Ivermectin does not cause toxicity
- Ivermectin had no impact on ATPase
- In the viruses mentioned in the chart, they all have the same or similar characteristics as the coronavirus (enveloped, positive-sense, single stranded)
- Ivermectin is very potent and thus can inhibit RNA replication in both the positive and negative strand

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